Starting testosterone replacement therapy (TRT) is a positive step toward improving your health and well-being. While many people experience significant benefits, it's also important to be aware of potential side effects. This guide is designed to help you understand these side effects, know what to look for, and learn how to manage them in partnership with your healthcare provider.
A Quick Note on Side Effects: Most side effects are mild and may lessen as your body adjusts to the new hormone levels. Serious side effects are rare, but it's important to know when to seek medical advice. Your healthcare provider will monitor you closely to ensure your treatment is both safe and effective.
Common Side Effects and How to Manage Them
Here’s a look at some of the more common side effects you might experience, along with tips for managing them. Remember, not everyone will experience these, and the severity can vary.
Side Effect | What It Is & Why It Happens | What You Can Do | When to Talk to Your Provider |
Acne and Oily Skin | Increased testosterone can cause your skin to produce more oil, which may lead to breakouts. |
| If acne becomes severe or bothersome. |
Mood Swings or Irritability | Your body is adjusting to new hormone levels, which can sometimes affect your mood. |
| If you experience significant or persistent mood changes. |
Fluid Retention | Testosterone can sometimes cause your body to hold on to more water, leading to a feeling of bloating or swelling, especially in the ankles. |
| If you notice sudden or significant swelling. |
Injection Site Reactions | If you are using injectable testosterone, you might experience temporary pain, redness, or swelling at the injection site. |
| If you experience severe pain, a large lump, or signs of infection (like pus or a fever). |
Changes in Libido | While many people experience an increase in libido, some may notice changes that are unexpected. |
| If you have any concerns about your libido. |
Less Common but Important Side Effects
These side effects are less frequent, but it's important to be aware of them.
Side Effect | What It Is & Why It Happens | What You Can Do | When to Talk to Your Provider |
Breast Tissue Growth (Gynecomastia) | An imbalance between testosterone and estrogen can sometimes cause breast tissue to swell or become tender. |
| Contact your provider right away if you notice any breast tenderness, swelling, or lumps. |
Increased Red Blood Cell Count | Testosterone can stimulate the production of red blood cells. If the count gets too high, it can increase the risk of blood clots. |
| Your provider will discuss management options with you if your levels are too high, which may include adjusting your dose or donating blood. |
Changes in Cholesterol Levels | TRT can sometimes affect your cholesterol levels. |
| Your provider will monitor your cholesterol levels as part of your routine blood work. |
High Blood Pressure | In some cases, testosterone therapy can lead to an increase in blood pressure. |
| If you notice a consistent increase in your blood pressure readings. |
When to Seek Immediate Medical Attention
While rare, some side effects require immediate medical attention. Call 911 or go to the nearest emergency room if you experience any of the following:
Signs of a blood clot: Sudden shortness of breath, chest pain, swelling or pain in one leg.
Signs of a heart attack or stroke: Chest pain, difficulty breathing, weakness on one side of your body, slurred speech.
Frequently Asked Questions (FAQs)
Q: Will these side effects go away?
A: Many of the more common side effects, like mood swings or skin changes, often improve or resolve as your body adjusts to the new hormone levels over the first few months of treatment. Others may require adjustments to your dosage or management strategies.
Q: What can I do to minimize the risk of side effects?
A: The best thing you can do is follow your provider's instructions carefully, attend all your follow-up appointments, and complete your lab work as scheduled. Living a healthy lifestyle with a balanced diet and regular exercise can also help.
Q: I'm worried about a side effect I'm experiencing. What should I do?
A: Don't hesitate to reach out to your healthcare provider. They are your best resource for information and can help you manage any side effects you're experiencing. It's always better to ask than to worry.
Your health and well-being are our top priorities. We are here to support you throughout your treatment journey. Please keep an open line of communication with your care team and report any concerns you may have.