What is Metformin?
Metformin is a widely-used oral medication for managing blood sugar levels, commonly prescribed for type 2 diabetes. It works by decreasing the amount of sugar your liver produces and improving your body's response to insulin. This guide will help you understand how to take your medication correctly, manage potential side effects, and follow the specific dosing protocol prescribed by your healthcare provider.
Note on Side Effects
Metformin is highly effective, but it can cause gastrointestinal (GI) side effects, such as nausea, diarrhea, or stomach upset, especially at higher doses. The key to minimizing these issues is a slow and careful dose increase (titration).
It is very important to check in with your provider if you experience side effects. Your dose can be adjusted to a level that is more manageable for you. To help pinpoint the cause of any side effects, especially when taking other medications like a GLP-1 agonist (e.g., semaglutide, tirzepatide).
Dosing Schedule:
Month | Dose | Frequency |
|---|---|---|
Month 1 - 2 | 500mg | once daily |
Month 3 - 4 | 500mg | 2x daily |
Month 5+ | 750mg | 2x daily |
Important Lab Monitoring
As part of your treatment plan, you will need to complete a Comprehensive Metabolic Panel (CMP) lab test at two key moments:
Month 1: To establish a baseline of your metabolic function.
Month 6: To monitor your progress and ensure the medication is working safely.
These tests are crucial for your provider to track your kidney and liver function. Please ensure you complete them on schedule.
Managing Side Effects
If you experience GI side effects, here are a few tips that can help:
Take it with food: Never take Metformin on an empty stomach.
Start low, go slow: Your dosing schedule is designed to increase slowly. Do not increase your dose faster than prescribed.
Talk to your provider: If side effects are persistent or bothersome, contact your healthcare provider. They may recommend temporarily reducing your dose or other strategies to help.
General Safety Information
Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take a double dose.
Alcohol: Limit alcohol consumption, as it can increase the risk of lactic acidosis, a rare but serious side effect.
Inform other doctors: Always inform any new doctor, dentist, or surgeon that you are taking Metformin.